Typical usage: Mild to moderate hypertension. Diabetic nephropathy in type 2 diabetes mellitus.

Side Effects: Headache, dizziness, back pain, myalgia, respiratory tract disorders, fatigue, GI disturbances, transient elevation of liver enzymes, impaired renal function, taste disturbances and hyperkalaemia.

Zaart -  Zaart helps to keep your blood pressure under control. Zaart relaxes your blood vessels and this helps to lower your blood pressure. It may be used on its own or together with other medicines. Zaart may also be used to treat other conditions, for example, heart failure and kidney disease in diabetic patients with high blood pressure.

Indications: hypertension

Drug Interaction:

               Losartan may increase levels of blood potassium (hyperkalemia), which can lead to serious heart problems (arrhythmias). Therefore, concomitant use of other drugs or substances that increase blood-such as potassium-sparing diuretics (for example, spironolactone[Aldactone], triamterene, and amiloride), potassium supplements, or salt substitutes containing potassium may lead to dangerous increases in serum potassium. Combining losartan or other ARBs with nonsteroidal anti-inflammatory drugs(NSAIDs) in patients who are elderly, fluid-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible. The antihypertensive effect of losartan may be reduced by aspirin and other NSAIDs such as ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, etc.), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve).

Dosage

Oral Hypertension Adult: Per tablet contains losartan 50 mg and hydrochlorothiazide 12.5 mg. For patients who are not adequately controlled on losartan or hydrochlorothiazide monotherapy: 1 tab once daily. May increase to 2 tabs once daily 2-4 wk later if needed. Max: 2 tabs/day.  Renal impairment: Dialysis patients: Avoid. CrCl (ml/min)Dosage Recommendation <20Avoid.

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Mechanism Of Action:

              Losartan is an angiotensin II receptor antagonist. The drug and its active metabolite selectively block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively antagonising its binding to AT1 receptors.