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  Exp. DATE    : 2015 / 03 OR LATER



                          400 mg Tablet                    :     Each sugarcoated tablet contains 400 mg ibuprofen

                       Brufen is indicated for its analgesic and anti-inflammatory effect in the treatment of rheumatoid arthritis (including juvenile rheumatoid arthritis or Still's disease), ankylosing spondylitis and osteo-arthritis, and acute gouty arthritis. Brufen is indicated in the treatment of non-articular rheumatism including fibrositis. Brufen is indicated in peri-articular conditions such as frozen shoulder (capsulitis), bursitis, tendinitis, tenosynovitis and low-back pain. Brufen can also be used in soft-tissue injuries such as sprains and strains. Brufen is also indicated for its analgesic effect in the relief of mild to moderate pain such as dysmenorrhoea, dental, post-episiotomy pain and post-partum pain. Brufen may also be used as an antipyretic.

                  Brufen should not be given to patients with peptic ulceration. The safety of Brufen in pregnancy has not been established.
Hypersensitivity to Ibuprofen, aspirin or any other non-steroidal anti-inflammatory agent. Because of the possibility of cross-sensitivity due to structural relationships which exist among non-steroidal anti-inflammatory medicines, acute allergic reactions may be more likely to occur in patients who have exhibited allergic reactions to these compounds.


Adults: The recommended dosage of Brufen is 1200 mg daily in divided doses. Some patients can be maintained on 600 to 1200 mg daily. In severe conditions it can be advantageous to increase the dosage until the acute phase has been brought under control.
To relieve early morning stiffness, the first dose of the day can be given immediately after the patient awakes.

For the relief of mild to moderate pain the following doses are recommended:
            ~ Dysmenorrhoea - 1200 mg per day in three divided doses. In cases of dental or post-episiotomy pain an initial dose of 800 mg may be given. The total daily dose of Brufen should not exceed 2400 mg. Once the acute phase has been brought under control, it is normal practice to revert to a maintenance dosage.
            ~ Acute gout: 2400 mg daily either as 800 mg 8 hourly or 600 mg 6 hourly until the acute symptoms have been relieved. If the acute symptoms do not resolve within three days, consult a doctor.
Children: In Juvenile Rheumatoid Arthritis, the total daily dosage of Brufen is 20 mg/kg of body mass given in divided doses.

Safety in children under one year of age has not been proven.
Pain: Initial dose 5 mg/kg of bodyweight.
A second dose of 5 mg/kg may be given after 2 hours if pain is not controlled, thereafter 5 mg/kg every 4 - 6 hours. DO NOT EXCEED 20 mg/kg of bodyweight per day. If pain persists for more than 7 days, consult your doctor.
Fever: 5 mg/kg of bodyweight every 4 - 6 hours. DO NOT EXCEED 20 mg/kg of bodyweight per day. If fever persists for more than 3 days, consult your doctor.

        Age                Bodyweight             Daily dosage in 5 mL spoonfuls
1 - 2 years              7 - 12 kg               2,5 mL up to 3 - 4 times daily
3 - 7 years             14 - 23 kg              2,5 - 5 mL up to 3 - 4 times daily
8 - 12 years           25 - 40 kg              10 mL up to 3 - 4 times daily

Do not give to children less than 7 kg or 1 year of age, except on the advice of your doctor.

        Tablets:                     Store below 25°C.
      Suspensions:             Store below 25°C. Protect against light. Shake well before use.





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